Thank you for the question. Neither I, nor my officials, have had any formal discussions with Vertex about Orkambi. I have, though, reminded Vertex that a medicine must be appraised and recommended by the National Institute for Health and Care Excellence or the All Wales Medicines Strategy Group before it can be routinely provided by NHS Wales. It is Vertex's responsibility to comply with the appraisal process, which they are both aware of and fully understand.