Now, I understand that many people are concerned that extending the interval between screenings will lead to missing cases of cervical cancer. But I'd like to assure people that HPV causes changes to the cells very slowly over several years, and that means that if there were to be cellular changes, they could be identified early on still in the next screening process. Screening more often than five years after a negative HPV result would be too early usually for any changes to the cells to come to the fore. So, the screening would not be beneficial and it could also give an incorrect reassurance to people. I'm pleased that Wales has led the way, and that we were the first nation in the UK to introduce those screens for high-risk HPV back in 2018. Scotland and England have now introduced those same tests for HPV, and in Scotland, the interval between screenings was extended some time ago, in March 2020.

Undoing that change to the interval for those at low risk would be a retrograde step. I acknowledge fully that more regular screening feels as though it would provide that additional reassurance, but, for those low-risk individuals, it doesn't provide the benefits that they would want to see. Extending the interval for those at low risk means that the screening programme can then focus on those high-risk individuals, who will be monitored more closely than in the past. We have to ensure that health services follow the science, and that they are provided only when they provide genuine benefit, and when there is a clinical need for them. So, that is the response to Buffy's comment about using this to talk about other health issues. It's very important that you are careful about how you use clinical interventions. We have to decrease possible harm in terms of providing those unnecessary interventions. Screening programmes need to evolve in response to cancer and developments in science. Just to respond to Jenny Rathbone—.